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Targeting Cullin-RING E3 Ligases for Radiosensitization: From NEDDylation Inhibition to PROTACs

As a dynamic regulator for short-lived protein degradation and turnover, the ubiquitin-proteasome system (UPS) plays important roles in various biological processes, including response to cellular stress, regulation of cell cycle progression, and carcinogenesis. Over the past decade, research on tar...

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Hlavní autoři: Shuhua Zheng, Wensi Tao
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020-08-01
Edice:Frontiers in Oncology
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On-line přístup:https://www.frontiersin.org/article/10.3389/fonc.2020.01517/full
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