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Flow-enhanced priming of hESCs through H2B acetylation and chromatin decondensation

Abstract Background Distinct mechanical stimuli are known to manipulate the behaviors of embryonic stem cells (ESCs). Fundamental rationale of how ESCs respond to mechanical forces and the potential biological effects remain elusive. Here we conducted the mechanobiological study for hESCs upon mecha...

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Autori principali: Jiawen Wang, Yi Wu, Xiao Zhang, Fan Zhang, Dongyuan Lü, Bing Shangguan, Yuxin Gao, Mian Long
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2019-11-01
Serie:Stem Cell Research & Therapy
Soggetti:
Embryonic stem cell
Fluid shear mechanomics
Nuclear spreading
Histone acetylation
Chromatin decondensation
Accesso online:http://link.springer.com/article/10.1186/s13287-019-1454-z
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