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Effect of Sperm DNA Fragmentation and Chromatin Decondensation on PLCζ Efficacy in Infertile Patients

This study aimed to describe phospholipase C zeta (PLCζ) deficiency from patients who experienced oocyte fertilization failure following intracytoplasmic sperm injection (ICSI) and to investigate the relationship between sperm DNA fragmentation, chromatin decondensation, and PLCζ. A total of 135 pat...

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Principais autores: Soukaina Azil, Ismail Kaarouch, Debbie Montjean, Marie-Hélène Godin Pagé, Rosalie Cabry, Noureddine Louanjli, Bouchra Ghazi, Moncef Benkhalifa
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-09-01
coleção:Current Issues in Molecular Biology
Assuntos:
PLCζ
DNA fragmentation
chromatin decondensation
fertilization failure
semen parameters
Acesso em linha:https://www.mdpi.com/1467-3045/47/9/707
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