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Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis

Abstract Background Sarcoidosis is a systemic granulomatous disease of unknown etiology primarily affecting the lungs. Treatment is needed when disease symptoms worsen and organ function deteriorates. In pulmonary sarcoidosis, prednisone and methotrexate (MTX) are the most common anti-inflammatory t...

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Principais autores: Raisa Kraaijvanger, Montse Janssen Bonás, Jan C. Grutters, Ioanna Paspali, Marcel Veltkamp, Dominique P. V. de Kleijn, Coline H. M. van Moorsel
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-04-01
Serier:Respiratory Research
Fag:
Extracellular vesicles
Sarcoidosis
Biomarkers
Therapy
Online adgang:https://doi.org/10.1186/s12931-024-02809-y
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