Hypoglycemia and hyperinsulinemia induced by phenolic uremic toxins in CKD and DKD patients

Abstract Patients with end-stage renal disease have lower fasting plasma glucose and HbA1c levels, with significantly higher insulin levels. For a long time, it has been believed that this higher insulin level in renal failure is due to decreased insulin clearance caused by reduced renal function. H...

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Autores principales:	Yoshiyasu Tongu, Tomoko Kasahara, Yasutoshi Akiyama, Takehiro Suzuki, Hsin-Jung Ho, Yotaro Matsumoto, Ryota Kujirai, Koichi Kikuchi, Koji Nata, Makoto Kanzaki, Kenshin Suzuki, Shun Watanabe, Chiharu Kawabe, Yui Miyata, Shun Itai, Takafumi Toyohara, Chitose Suzuki, Tetsuhiro Tanaka, Jun Wada, Yoshihisa Tomioka, Takaaki Abe
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-02-01
Colección:	Scientific Reports
Materias:	CKD DKD Phenyl sulfate Uremic toxin Insulin secretion Insulin resistance
Acceso en línea:	https://doi.org/10.1038/s41598-025-87501-x
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