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Exposure-response analyses of efzofitimod in patients with pulmonary sarcoidosis

Background: Preliminary evidence for efficacy in pulmonary sarcoidosis has been shown for efzofitimod. Here we present supportive evidence of efficacy based on an exposure-response analysis.Methods: Data from two studies (Phase 1, N = 24, single dose in healthy volunteers, and Phase 1b/2a, N = 25, m...

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Principais autores: Gennyne Walker, Ryan Adams, Lauren Guy, Abhijeeth Chandrasekaran, Nelson Kinnersley, Pavithra Ramesh, Lu Zhang, Fran Brown, Vis Niranjan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2023-10-01
coleção:Frontiers in Pharmacology
Assuntos:
efzofitimod
pulmonary sarcoidosis treatment
exposure-response relationship
steroid-sparing effect
forced vital capacity
King’s Sarcoidosis Questionnaire-Lung
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2023.1258236/full
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