Exploration of precision coregulator TR-FRET identifies diverse signatures for LXR ligands relevant to discovery of nonlipogenic ABCA1 inducers

APOE4, the major genetic risk factor for Alzheimer’s disease (AD), and ATP-binding cassette-A1 (ABCA1), required for lipidation of APOE are gene products of the liver X receptor (LXR) receptor. LXR agonists have been validated in animal models as therapeutics for AD, atherosclerosis, and many other...

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Autors principals:	Megan S Laham, Martha S Ackerman-Berrier, Fahmida Alam, Sarah Turner, Ganga Reddy Velma, Christopher Penton, Soumya Reddy Musku, Manan Rana, Senthilkumar Thulasingam, Anandhan Annadurai, Maha Ibrahim Sulaiman, Nina Ma, Gregory RJ Thatcher
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2026-06-01
Col·lecció:	eLife
Matèries:	liver X receptor LXR ATP-binding cassette-A1 coregulator selectivity lipogenesis
Accés en línia:	https://elifesciences.org/articles/109146
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