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BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

Abstract Background Interferons (IFNs) are key cytokines that drive immune responses against infections and cancer, yet few therapies have successfully leveraged IFN signaling for cancer treatment. Long noncoding RNAs (lncRNAs) are emerging as promising therapeutic candidates, but their roles in imm...

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Автори: Haran Sivakumaran, Sneha Nair, Mainá Bitar, Xue Lu, Lu Wang, Ji Liu, Deshapriya S. Karunarathne, P. Prakrithi, Sebastien Jacquelin, Isela Sarahi Rivera, Kristine M. Hillman, Susanne Kaufmann, Rebekah Ziegman, Wei Shi, Sarah Alexandrou, C. Elizabeth Caldon, Rakesh N. Veedu, Quan H. Nguyen, Jonathan Beesley, Michelle N. Wykes, Juliet D. French, Stacey L. Edwards
Формат: Artigo
Мова:Inglês
Опубліковано: BMC 2026-01-01
Серія:Molecular Cancer
Предмети:
Breast cancer
Long noncoding RNA
LncRNA
BRRIAR
BHLHE40
RIG-I
Онлайн доступ:https://doi.org/10.1186/s12943-025-02510-8
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