BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans

Abstract Background Interferons (IFNs) are key cytokines that drive immune responses against infections and cancer, yet few therapies have successfully leveraged IFN signaling for cancer treatment. Long noncoding RNAs (lncRNAs) are emerging as promising therapeutic candidates, but their roles in imm...

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Autores principales:	Haran Sivakumaran, Sneha Nair, Mainá Bitar, Xue Lu, Lu Wang, Ji Liu, Deshapriya S. Karunarathne, P. Prakrithi, Sebastien Jacquelin, Isela Sarahi Rivera, Kristine M. Hillman, Susanne Kaufmann, Rebekah Ziegman, Wei Shi, Sarah Alexandrou, C. Elizabeth Caldon, Rakesh N. Veedu, Quan H. Nguyen, Jonathan Beesley, Michelle N. Wykes, Juliet D. French, Stacey L. Edwards
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2026-01-01
Colección:	Molecular Cancer
Materias:	Breast cancer Long noncoding RNA LncRNA BRRIAR BHLHE40 RIG-I
Acceso en línea:	https://doi.org/10.1186/s12943-025-02510-8
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