Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

The mammalian prions replicate by converting cellular prion protein (PrP(C)) into pathogenic conformational isoform (PrP(Sc)). Variations in prions, which cause different disease phenotypes, are referred to as strains. The mechanism of high-fidelity replication of prion strains in the absence of nuc...

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Hlavní autoři:	Chae Kim, Tracy Haldiman, Krystyna Surewicz, Yvonne Cohen, Wei Chen, Janis Blevins, Man-Sun Sy, Mark Cohen, Qingzhong Kong, Glenn C Telling, Witold K Surewicz, Jiri G Safar
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Public Library of Science (PLoS) 2012-01-01
Edice:	PLoS Pathogens
On-line přístup:	http://europepmc.org/articles/PMC3410855?pdf=render
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