PrPSc with Seeding Activity Extensively Overlaps with Proteinase-Resistant PrPSc Rather than Infectious PrPSc

The disease-associated prion protein (PrPSc) has the ability to seed the conformational conversion of normal prion proteins into the amyloid fibril form. This prion seeding activity can be measured using an in vitro amplification assay termed real-time quaking-induced conversion (RT-QuIC). There is...

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Principais autores:	Yoshifumi Iwamaru, Yuichi Matsuura, Kohtaro Miyazawa
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2020-03-01
Serija:	Pathogens
Teme:	amyloid bovine spongiform encephalopathy hamster infectivity kinetics mouse model prion real-time quaking induced conversion (rt-quic) scrapie seeding activity
Online dostop:	https://www.mdpi.com/2076-0817/9/3/241
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