Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo

In this investigation, we extensively studied the mechanism of antitumor activity of bovine pancreatic RNase A. Using confocal microscopy, we show that after RNase A penetration into HeLa and B16 cells, a part of the enzyme remains unbound with the ribonuclease inhibitor (RI), resulting in the decre...

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Detalhes bibliográficos

Principais autores:	Islam Saber Ead Mohamed, Aleksandra V. Sen’kova, Oleg V. Markov, Andrey V. Markov, Innokenty A. Savin, Marina A. Zenkova, Nadezhda L. Mironova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-05-01
coleção:	Pharmaceutics
Assuntos:	RNase A ribonuclease inhibitor antitumor activity intracellular localization Ku70/Ku80 miRNA
Acesso em linha:	https://www.mdpi.com/1999-4923/14/6/1173
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