Macrophage-mediated tumor-targeted delivery of engineered Salmonella typhimurium VNP20009 in anti-PD1 therapy against melanoma

Bacterial antitumor therapy has great application potential given its unique characteristics, including genetic manipulation, tumor targeting specificity and immune system modulation. However, the nonnegligible side effects and limited efficacy of clinical treatment limit their biomedical applicatio...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Leyang Wu, Lin Li, Shufeng Li, Lina Liu, Wenjie Xin, Chenyang Li, Xingpeng Yin, Xuebo Xu, Feifei Bao, Zichun Hua
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2022-10-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	Macrophage Salmonella typhimurium VNP20009 Anti-PD1 nanobody Tumor-targeted delivery Immune activation
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S221138352200212X
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!