Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry

Abstract The prevalence of autoimmune diseases such as inflammatory bowel disease (IBD) and rheumatoid arthritis (RA) is increasing. Glucocorticoid-induced TNFR-related protein (GITR), a TNF receptor superfamily (TNFRSF) member, is activated by GITR-ligand (GITRL). GITR signaling is pathogenic in mo...

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Главные авторы:	Jing Yan, Jessica Min-DeBartolo, Ching-Shin Huang, M. Nusrat Sharif, Li Li, Susan Fish, Corey Dower, Denise Murphy, Tatyana Andreyeva, Heng Liu, Xinbing Han, Wei Zheng, Jot Hui Ooi, Jason Edmonds, Ting Chen, Zachary Maben, Chad R. Stevens, Polina Goihberg, Malgorzata Nocula-Lugowska, Steven M Evans, Lidia Mosyak, Kerry Kelleher, Caitlyn Dickinson, Martin Hegen, Aaron Winkler, Fridrik Karlsson
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2025-12-01
Серии:	Scientific Reports
Online-ссылка:	https://doi.org/10.1038/s41598-025-32541-6
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