GITRL impairs hepatocyte repopulation by liver progenitor cells to aggravate inflammation and fibrosis by GITR+CD8+ T lymphocytes in CDE Mice

Abstract As an alternative pathway for liver regeneration, liver progenitor cells and their derived ductular reaction cells increase during the progression of many chronic liver diseases. However, the mechanism underlying their hepatocyte repopulation after liver injury remains unknown. Here, we con...

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Hlavní autoři:	Li Li, Yu He, Kai Liu, Lin Liu, Shan Shan, Helin Liu, Jiangbo Ren, Shujie Sun, Min Wang, Jidong Jia, Ping Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Nature Publishing Group 2024-02-01
Edice:	Cell Death and Disease
On-line přístup:	https://doi.org/10.1038/s41419-024-06506-y
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