C2 IgM Natural Antibody Enhances Inflammation and Its Use in the Recombinant Single Chain Antibody-Fused Complement Inhibitor C2-Crry to Target Therapeutics to Joints Attenuates Arthritis in Mice

Natural IgM antibodies (NAbs) have been shown to recognize injury-associated neoepitopes and to initiate pathogenic complement activation. The NAb termed C2 binds to a subset of phospholipids displayed on injured cells, and its role(s) in arthritis, as well as the potential therapeutic benefit of a...

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Principais autores:	Nirmal K. Banda, Stephen Tomlinson, Robert I. Scheinman, Nhu Ho, Joseline Ramos Ramirez, Gaurav Mehta, Guankui Wang, Vivian Pham Vu, Dmitri Simberg, Liudmila Kulik, V. Michael Holers
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2020-10-01
coleção:	Frontiers in Immunology
Assuntos:	natural antibodies single chain C2-Crry complement complement inhibitor arthritis
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2020.575154/full
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