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A careful look at lipid nanoparticle characterization: analysis of benchmark formulations for encapsulation of RNA cargo size gradient

Abstract With the recent success of lipid nanoparticle (LNP) based SARS-CoV-2 mRNA vaccines, the potential for RNA therapeutics has gained widespread attention. LNPs are promising non-viral delivery vectors to protect and deliver delicate RNA therapeutics, which are ineffective and susceptible to de...

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Autori principali: Gretchen B. Schober, Sandra Story, Dev P. Arya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2024-01-01
Serie:Scientific Reports
Accesso online:https://doi.org/10.1038/s41598-024-52685-1
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