Tracing the tissue origin of cell-free DNA through open chromatin footprint

Abstract Plasma cell-free DNA (cfDNA) is a promising biomarker for liquid biopsy, essential for diagnosing and monitoring diseases. Current methods for estimating tissue contributions primarily rely on methylation markers, which can damage cfDNA, limiting clinical use. While research shows cfDNA cov...

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Bibliografski detalji

Glavni autori:	Lingguo Li, Xiameizi Li, Yongjie Li, Fengxia Su, Yan Zhang, Zhuangyuan Tang, Jinghua Sun, Ya Gao, Xin Jin, Haiqiang Zhang
Format:	Artigo
Jezik:	Inglês
Izdano:	Nature Portfolio 2025-11-01
Serija:	Communications Biology
Online pristup:	https://doi.org/10.1038/s42003-025-09232-z
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