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The relationship between the pharmacogenetics and pharmacokinetics of CFTR modulators in a population of children with cystic fibrosis

The triple combination of elexacaftor / tezacaftor / ivacaftor is one of the key tools for targeted pharmacotherapy of cystic fibrosis. In the pediatric population, its use may be accompanied by a variable therapeutic response, which may be due to age-related pharmacokinetic features, as well as the...

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Principais autores: S. K. Zyryanov, E. I. Kondratyeva, E. K. Zhekaite, O. I. Butranova, P. O. Bochkov
Format: Artigo
Sprog:Russo
Udgivet: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute 2026-07-01
Serier:Фармация и фармакология (Пятигорск)
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Online adgang:https://www.pharmpharm.ru/jour/article/view/1921
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