Natural Product Isoliquiritigenin Activates GABA_B Receptors to Decrease Voltage-Gate Ca²⁺ Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals

Reduction in glutamate release is a key mechanism for neuroprotection and we investigated the effect of isoliquiritigenin (ISL), an active ingredient of Glycyrrhiza with neuroprotective activities, on glutamate release in rat cerebrocortical nerve terminals (synaptosomes). ISL produced a concentrati...

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Ngā kaituhi matua:	Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	MDPI AG 2021-10-01
Rangatū:	Biomolecules
Ngā marau:	isoliquiritigenin GABA<sub>B</sub> receptors G<sub>βγ</sub> VGCCs glutamate cerebrocortical synaptosomes
Urunga tuihono:	https://www.mdpi.com/2218-273X/11/10/1537
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!