Natural Product Isoliquiritigenin Activates GABA_B Receptors to Decrease Voltage-Gate Ca²⁺ Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals

Reduction in glutamate release is a key mechanism for neuroprotection and we investigated the effect of isoliquiritigenin (ISL), an active ingredient of Glycyrrhiza with neuroprotective activities, on glutamate release in rat cerebrocortical nerve terminals (synaptosomes). ISL produced a concentrati...

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Detalhes bibliográficos

Principais autores:	Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2021-10-01
coleção:	Biomolecules
Assuntos:	isoliquiritigenin GABA<sub>B</sub> receptors G<sub>βγ</sub> VGCCs glutamate cerebrocortical synaptosomes
Acesso em linha:	https://www.mdpi.com/2218-273X/11/10/1537
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