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Novel therapeutic strategies targeting telomere maintenance mechanisms in high-risk neuroblastoma

Abstract The majority of high-risk neuroblastomas can be divided into three distinct molecular subgroups defined by the presence of MYCN amplification, upstream TERT rearrangements or alternative lengthening of telomeres (ALT). The common defining feature of all three subgroups is altered telomere m...

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Autors principals: S. L. George, V. Parmar, F. Lorenzi, L. V. Marshall, Y. Jamin, E. Poon, P. Angelini, L. Chesler
Format: Artigo
Idioma:Inglês
Publicat: BMC 2020-05-01
Col·lecció:Journal of Experimental & Clinical Cancer Research
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Accés en línia:http://link.springer.com/article/10.1186/s13046-020-01582-2
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