Charge reduction and thermodynamic stabilization of substrate RNAs inhibit RNA editing.

African trypanosomes cause a parasitic disease known as sleeping sickness. Mitochondrial transcript maturation in these organisms requires a RNA editing reaction that is characterized by the insertion and deletion of U-nucleotides into otherwise non-functional mRNAs. Editing represents an ideal targ...

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Autores principales:	W-Matthias Leeder, Andreas J Reuss, Michael Brecht, Katja Kratz, Josef Wachtveitl, H Ulrich Göringer
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Public Library of Science (PLoS) 2015-01-01
Colección:	PLoS ONE
Acceso en línea:	https://doi.org/10.1371/journal.pone.0118940
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