NR4A1 deletion promotes pro-angiogenic polarization of macrophages derived from classical monocytes in a mouse model of neovascular age-related macular degeneration

Abstract Background Neovascular age-related macular degeneration causes vision loss from destructive angiogenesis, termed choroidal neovascularization (CNV). Cx3cr1 −/− mice display alterations in non-classical monocytes and microglia with increased CNV size, suggesting that non-classical monocytes...

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Bibliografische gegevens

Hoofdauteurs:	Steven Droho, Andrew P. Voigt, Jacob K. Sterling, Amrita Rajesh, Kyle S. Chan, Carla M. Cuda, Harris Perlman, Jeremy A. Lavine
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	BMC 2023-10-01
Reeks:	Journal of Neuroinflammation
Onderwerpen:	Angiogenesis Choroidal neovascularization Macrophage Monocyte Non-classical monocytes Neovascular age-related macular degeneration
Online toegang:	https://doi.org/10.1186/s12974-023-02928-1
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