Lactate metabolic reprogramming and lactylation modification: molecular mechanisms reshaping the tumor immunosuppressive microenvironment

Abstract The immunosuppressive tumor microenvironment (TME) remains a major therapeutic challenge in oncology. This immunosuppression arises through two synergistic mechanisms: impaired cytotoxic function of T cells and NK cells, and differentiation of immune cells into immunosuppressive subtypes. M...

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Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Yuzhang Yuan, Yaping Gao, Jinhui Xue, Haozhe Zhang, Ruiting Liang, Luying Huang, Zehua Wang, Liang Song, Yanru Qin, Jiaoyu Ai
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	BMC 2026-04-01
Цуврал:	Cell & Bioscience
Нөхцлүүд:	Lactate metabolism Tumor microenvironment Immunosuppression Warburg effect Metabolic reprogramming
Онлайн хандалт:	https://doi.org/10.1186/s13578-026-01572-5
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!