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Lipid accumulation in human breast cancer cells injured by iron depletors

Abstract Background Current insights into the effects of iron deficiency in tumour cells are not commensurate with the importance of iron in cell metabolism. Studies have predominantly focused on the effects of oxygen or glucose scarcity in tumour cells, while attributing insufficient emphasis to th...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Maida De Bortoli, Elena Taverna, Elisa Maffioli, Patrizia Casalini, Francesco Crisafi, Vikas Kumar, Claudio Caccia, Dario Polli, Gabriella Tedeschi, Italia Bongarzone
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-04-01
Schriftenreihe:Journal of Experimental & Clinical Cancer Research
Schlagworte:
Breast cancer
cytoplasm vacuolation
endoplasmic reticulum stress
iron chelation
lipid droplets
macropinocytosis
Online-Zugang:http://link.springer.com/article/10.1186/s13046-018-0737-z
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