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Indole-Based Tubulin Inhibitors: Binding Modes and SARs Investigations

Tubulin inhibitors can interfere with normal cell mitosis and inhibit cell proliferation through interfering with the normal structure and function of microtubules, forming spindle filaments. Indole, as a privileged pharmacological skeleton, has been widely used in anti-cancer inhibitors. A variety...

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Principais autores: Sheng Tang, Zhihui Zhou, Zhiyan Jiang, Wufu Zhu, Dan Qiao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-02-01
Serier:Molecules
Fag:
tubulin inhibitors
indole
cancer
binding modes
SARs investigations
Online adgang:https://www.mdpi.com/1420-3049/27/5/1587
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