Pharmacological evaluation of physcion as a TRPV1 inhibitor with multimodal analgesic efficacy in experimental pain models

Abstract Background Pain serves as a vital protective mechanism triggered by tissue damage. While NSAIDs and opioids offer relief, their prolonged usage is hindered by adverse effects. Developing analgesics with fewer side effects is crucial for effective pain treatment. The TRPV1 channel is a key t...

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Autors principals:	Hanbin Chen, Guanghong Li, Lin Deng, Shuli Li, Songqiang Huang, Simon Ming-Yuen Lee, Xiaowei Nie, Jin-Song Bian
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-07-01
Col·lecció:	Biological Research
Matèries:	Physcion Virtual screening Molecular dynamics simulation Aanalgesic Anti-inflammation
Accés en línia:	https://doi.org/10.1186/s40659-025-00630-5
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