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Discovery of Rhubarb Anthraquinones Physcion and Rhein as Functional Inhibitors of TRPV1 Against Lipopolysaccharide-Induced Neuroinflammation

Neuroinflammation, mediated by microglia and astrocytes, is an abnormal immune reaction in central nervous system (CNS) disorders. Stimulation of TRPV1 has been found to enhance microglial activation, resulting in a pro-inflammatory response. Natural anthraquinones such as physcion and rhein are com...

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Principais autores: Shuli Li, Yulin He, Hiotong Kam, Hanbin Chen, Jin-Song Bian, Nan Xu, Guiyi Gong, Qiwen Liao, Chen Zhao, Binrui Yang, Liang Chen, Kit Ieng Kuok, Simon Ming Yuen Lee
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Molecules
Fag:
rhubarb
anthraquinones
physcion
rhein
neuroinflammation
TRPV1
Online adgang:https://www.mdpi.com/1420-3049/31/12/2049
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