Proteome-wide Mendelian randomization and colocalization analysis uncovers druggable targets for lung cancer across multiple phenotypes and complications

Abstract Background Lung cancer remains a leading cause of cancer-related mortality, necessitating novel therapeutic targets. The plasma proteome represents a key source for such targets. Methods Proteome-wide Mendelian randomization (MR) and colocalization analyses were conducted to assess the caus...

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Autors principals:	Yunpeng Chen, Xiaohong Dai, Peng Zhang, Lijuan Yao, Qing Wang, Zhihong Qin, Tianmin Gao, Junguo Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer 2025-11-01
Col·lecció:	Discover Oncology
Matèries:	Mendelian randomization Lung cancer Therapeutic targets Proteome-wide analysis
Accés en línia:	https://doi.org/10.1007/s12672-025-03910-4
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