β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice
Objective: Notch signaling, re-activated in β cells from obese mice and causal to β cell dysfunction, is determined in part by transmembrane ligand availability in a neighboring cell. We hypothesized that β cell expression of Jagged1 determines the maladaptive Notch response and resultant insulin se...
שמור ב:
| Principais autores: | , , , , , , , , |
|---|---|
| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
Elsevier
2024-03-01
|
| סדרה: | Molecular Metabolism |
| נושאים: | |
| גישה מקוונת: | http://www.sciencedirect.com/science/article/pii/S2212877824000255 |
| תגים: |
אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!
|