β-cell Jagged1 is sufficient but not necessary for islet Notch activity and insulin secretory defects in obese mice

Objective: Notch signaling, re-activated in β cells from obese mice and causal to β cell dysfunction, is determined in part by transmembrane ligand availability in a neighboring cell. We hypothesized that β cell expression of Jagged1 determines the maladaptive Notch response and resultant insulin se...

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Hlavní autoři:	Nina Suda, Alberto Bartolomé, Jiani Liang, Jinsook Son, Yoko Yagishita, Christian Siebel, Domenico Accili, Hongxu Ding, Utpal B. Pajvani
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-03-01
Edice:	Molecular Metabolism
Témata:	Notch Jagged1 Beta cell Alpha cell Insulin secretion Diabetes
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2212877824000255
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