A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective

The lipid electrophile nitro-oleic acid (NO2-OA) and inhibitors of soluble epoxide hydrolase (sEH) limit injury during myocardial ischemia and reperfusion (IR). We investigated if cardioprotection by NO2-OA was mediated by inhibitory adduction of this electrophile to C521 of the hydrolase. Indeed, a...

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Bibliographic Details

Main Authors:	Rebecca L. Charles, Mariana Fernandez-Caggiano, Olena Rudyk, Izaak Tyson-Hirst, Mazdak Ehteramyan, Christopher H. Switzer, Roberto Buccafusca, Vinothini Rajeeve, Katiuscia Bianchi, Valle Morales, Andrew J. Finch, Philip Eaton
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-02-01
Series:	Redox Biology
Subjects:	Soluble epoxide hydrolase Inhibitor Thiol Heart Ischemia and reperfusion
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231725004872
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