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A novel inhibitor of soluble epoxide hydrolase that adducts C521 is cardioprotective

The lipid electrophile nitro-oleic acid (NO2-OA) and inhibitors of soluble epoxide hydrolase (sEH) limit injury during myocardial ischemia and reperfusion (IR). We investigated if cardioprotection by NO2-OA was mediated by inhibitory adduction of this electrophile to C521 of the hydrolase. Indeed, a...

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Principais autores: Rebecca L. Charles, Mariana Fernandez-Caggiano, Olena Rudyk, Izaak Tyson-Hirst, Mazdak Ehteramyan, Christopher H. Switzer, Roberto Buccafusca, Vinothini Rajeeve, Katiuscia Bianchi, Valle Morales, Andrew J. Finch, Philip Eaton
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-02-01
coleção:Redox Biology
Assuntos:
Soluble epoxide hydrolase
Inhibitor
Thiol
Heart
Ischemia and reperfusion
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231725004872
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