A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

Background: Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic cancer. Here, we investigated VEDT in patients with pancreatic ductal neoplasia in a window-of-opportunity preoperative clinical tri...

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Detalhes bibliográficos

Principais autores:	Gregory M. Springett, Kazim Husain, Anthony Neuger, Barbara Centeno, Dung-Tsa Chen, Tai Z. Hutchinson, Richard M. Lush, Saïd Sebti, Mokenge P. Malafa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2015-12-01
coleção:	EBioMedicine
Assuntos:	Vitamin E Tocotrienols Presurgical trial Pancreatic cancer Chemoprevention
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352396415302073
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