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A Phase I Safety, Pharmacokinetic, and Pharmacodynamic Presurgical Trial of Vitamin E δ-tocotrienol in Patients with Pancreatic Ductal Neoplasia

Background: Vitamin E δ-tocotrienol (VEDT), a natural vitamin E from plants, has shown anti-neoplastic and chemoprevention activity in preclinical models of pancreatic cancer. Here, we investigated VEDT in patients with pancreatic ductal neoplasia in a window-of-opportunity preoperative clinical tri...

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Principais autores: Gregory M. Springett, Kazim Husain, Anthony Neuger, Barbara Centeno, Dung-Tsa Chen, Tai Z. Hutchinson, Richard M. Lush, Saïd Sebti, Mokenge P. Malafa
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-12-01
Serier:EBioMedicine
Fag:
Vitamin E
Tocotrienols
Presurgical trial
Pancreatic cancer
Chemoprevention
Online adgang:http://www.sciencedirect.com/science/article/pii/S2352396415302073
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