The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro

DLL1 and DLL4 are Notch ligands with high structural similarity but context-dependent functional differences. Here, we analyze their functional divergence using cellular co-culture assays, biochemical studies, and in vivo experiments. DLL1 and DLL4 activate NOTCH1 and NOTCH2 differently in cell-base...

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Hlavní autoři:	Lena Tveriakhina, Karin Schuster-Gossler, Sanchez M Jarrett, Marie B Andrawes, Meike Rohrbach, Stephen C Blacklow, Achim Gossler
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	eLife Sciences Publications Ltd 2018-10-01
Edice:	eLife
Témata:	DLL1 DLL4 notch receptor selectivity functional divergence ectodomain
On-line přístup:	https://elifesciences.org/articles/40045
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