A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts

IntroductionThe standard treatment for preventing rejection in vascularized composite allotransplantation (VCA) currently relies on systemic immunosuppression, which exposes the host to well-known side effects. Locally administered immunosuppression strategies have shown promising results to bypass...

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Auteurs principaux:	Isabel Arenas Hoyos, Anja Helmer, Anaïs Yerly, Ioana Lese, Stefanie Hirsiger, Lei Zhang, Daniela Casoni, Luisana Garcia, MariaFrancesca Petrucci, Sabine E. Hammer, Tereza Duckova, Yara Banz, Matteo Montani, Mihai Constantinescu, Esther Vögelin, Gregor Bordon, Simone Aleandri, Jean-Christophe Prost, Adriano Taddeo, Paola Luciani, Robert Rieben, Nicoletta Sorvillo, Radu Olariu
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2024-06-01
Collection:	Frontiers in Immunology
Sujets:	vascularized composite allotransplantation (VCA) transplantation immunology tacrolimus local immunosuppression calcineurin inhibitors (CNIs) drug delivery systems (DDSs)
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387945/full
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