A local drug delivery system prolongs graft survival by dampening T cell infiltration and neutrophil extracellular trap formation in vascularized composite allografts

IntroductionThe standard treatment for preventing rejection in vascularized composite allotransplantation (VCA) currently relies on systemic immunosuppression, which exposes the host to well-known side effects. Locally administered immunosuppression strategies have shown promising results to bypass...

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প্রধান লেখক:	Isabel Arenas Hoyos, Anja Helmer, Anaïs Yerly, Ioana Lese, Stefanie Hirsiger, Lei Zhang, Daniela Casoni, Luisana Garcia, MariaFrancesca Petrucci, Sabine E. Hammer, Tereza Duckova, Yara Banz, Matteo Montani, Mihai Constantinescu, Esther Vögelin, Gregor Bordon, Simone Aleandri, Jean-Christophe Prost, Adriano Taddeo, Paola Luciani, Robert Rieben, Nicoletta Sorvillo, Radu Olariu
বিন্যাস:	Artigo
ভাষা:	Inglês
প্রকাশিত:	Frontiers Media S.A. 2024-06-01
মালা:	Frontiers in Immunology
বিষয়গুলি:	vascularized composite allotransplantation (VCA) transplantation immunology tacrolimus local immunosuppression calcineurin inhibitors (CNIs) drug delivery systems (DDSs)
অনলাইন ব্যবহার করুন:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1387945/full
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