Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation

Abstract In the United States, impaired bone healing impacts ~600,000 patients annually. Bone morphogenetic protein 2 (rhBMP2) therapy is impeded by low bone quality and adverse effects. Here, mesenchymal stem cells, engineered to produce BMP2 and BMP2/7 containing extracellular vesicles (BMP2-EV an...

詳細記述

書誌詳細

主要な著者:	Zeji Du, Skylar A. Rizzo, Tiffany L. Sarrafian, Monique S. Bagwell, Ryan C. Mahlberg, Ashley Amontree, Paige Schiebel, Dinah M. Tauferner, Zoe S. LeBrasseur, Tyra A. Witt, Mary Nagel, Kyla A. Boyd, Humberto De Vitto, Matthew L. Hillestad, Paul G. Stalboerger, Matthew T. Houdek, Rafael J. Sierra, Atta Behfar
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-06-01
シリーズ:	npj Regenerative Medicine
オンライン･アクセス:	https://doi.org/10.1038/s41536-025-00405-2
タグ:	タグ追加 タグなし, このレコードへの初めてのタグを付けませんか!