Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation

Abstract In the United States, impaired bone healing impacts ~600,000 patients annually. Bone morphogenetic protein 2 (rhBMP2) therapy is impeded by low bone quality and adverse effects. Here, mesenchymal stem cells, engineered to produce BMP2 and BMP2/7 containing extracellular vesicles (BMP2-EV an...

Descripció completa

Guardat en:

Dades bibliogràfiques
Autors principals:	Zeji Du, Skylar A. Rizzo, Tiffany L. Sarrafian, Monique S. Bagwell, Ryan C. Mahlberg, Ashley Amontree, Paige Schiebel, Dinah M. Tauferner, Zoe S. LeBrasseur, Tyra A. Witt, Mary Nagel, Kyla A. Boyd, Humberto De Vitto, Matthew L. Hillestad, Paul G. Stalboerger, Matthew T. Houdek, Rafael J. Sierra, Atta Behfar
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-06-01
Col·lecció:	npj Regenerative Medicine
Accés en línia:	https://doi.org/10.1038/s41536-025-00405-2
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Engineered BMP2/BMP7 extracellular vesicles induce autocrine BMP release driving SMAD phosphorylation to promote bone formation

Ítems similars