Tyrosine 48 Phosphorylation of Cytochrome <i>c</i> Alters Mitochondrial Respiration, ROS Production, and Apoptosis

Cytochrome <i>c</i> (Cyt<i>c</i>) tyrosine 48 (Y48) has been previously shown to be phosphorylated in bovine liver, and phosphomimetic substitution (Y48E) inhibits key functions of Cyt<i>c</i> in vitro, including respiration and apoptosis. In this study, we investigated the effect of Y48 modificatio...

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Detalhes bibliográficos

Principais autores:	Paul T. Morse, Susanna Vuljaj, Nabil Yazdi, Matthew P. Zurek, Junmei Wan, Icksoo Lee, Asmita Vaishnav, Brian F.P. Edwards, Tasnim Arroum, Maik Hüttemann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-04-01
coleção:	Biomolecules
Assuntos:	mitochondria hepatic liver cytochrome <i>c</i> electron transport chain apopotosis
Acesso em linha:	https://www.mdpi.com/2218-273X/16/5/632
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