Peptides developed against receptor binding sites of the E glycoprotein neutralize tick-borne encephalitis virus

Abstract Infection caused by tick-borne encephalitis virus (TBEV) often manifests with meningitis or encephalitis. Domain III (DIII) of the envelope (E) glycoprotein on the TBEV surface facilitates virion attachment to the cell receptor and initiates cell entry. As a result, this research focused on...

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Detalhes bibliográficos
Main Authors: Patrícia Petroušková, Katarína Bhide, Evelína Mochnáčová, Amod Kulkarni, Jana Jozefiaková, Zuzana Tkáčová, Tomáš Maľarik, Katarína Kucková, Lea Talpašová, Jakub Víglaský, Ádám Kevély, Kamila Koči, Eva Nováková, Juraj Koči, Mangesh Bhide
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-04-01
Colecção:Scientific Reports
Assuntos:
Tick-borne encephalitis virus
Domain III
Blocking peptides
Phage display
hBMECs
PRNT
Acesso em linha:https://doi.org/10.1038/s41598-025-95449-1
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