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Integration of transcriptomic data reveals lipid metabolic heterogeneity and identifies GSTO1 as a therapeutic target in acute myeloid leukemia

BackgroundAcute myeloid leukemia (AML) is an aggressive hematologic malignancy with poor prognosis and significant heterogeneity. Lipid metabolic reprogramming is a key hallmark of cancer, yet its systemic characterization and clinical relevance in AML remain largely unexplored.MethodsMulti-omics da...

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Principais autores: Fangmin Zhong, Zihao Wang, Jialin Huang, Linfeng Jin, Fangyi Yao, Xiaozhong Wang
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Immunology
Fag:
acute myeloid leukemia
GSTO1
immunotherapy
lipid metabolism
prognostic signature
tumor microenvironment
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1815163/full
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