Suppression of astrocytic autophagy by αB-crystallin contributes to α-synuclein inclusion formation

Abstract Background Parkinson’s disease (PD) is characterized by a chronic loss of dopaminergic neurons and the presence of proteinaceous inclusions (Lewy bodies) within some remaining neurons in the substantia nigra. Recently, astroglial inclusion body has also been found in some neurodegenerative...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Shen-zhao Lu, Yong-shun Guo, Pei-zhou Liang, Shu-zhen Zhang, Shu Yin, Yan-qing Yin, Xiao-min Wang, Fei Ding, Xiao-song Gu, Jia-wei Zhou
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2019-01-01
Schriftenreihe:	Translational Neurodegeneration
Schlagworte:	αB-crystallin Astrocytes Parkinson’s disease Autophagy
Online-Zugang:	http://link.springer.com/article/10.1186/s40035-018-0143-7
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