Effects of perioperative dexmedetomidine on renal vascular function and renovascular histopathology in ovine cardiopulmonary bypass

Abstract Background Cardiopulmonary bypass (CPB) is integral to the conduct of cardiac surgery but is associated with postoperative acute kidney injury (AKI). Dexmedetomidine, an α₂-adrenoceptor agonist with anti-inflammatory and sympatholytic properties, has putative renoprotective effects. In a re...

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Autori principali:	Ashenafi H. Betrie, Alemayehu H. Jufar, Roger G. Evans, Andrew D. Cochrane, Bruno Marino, Ian Birchall, Sally G. Hood, Peter R. McCall, Scott Ayton, Lachlan F. Miles, Clive N. May, Yugeesh R. Lankadeva
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	SpringerOpen 2025-12-01
Serie:	Intensive Care Medicine Experimental
Soggetti:	Cardiopulmonary bypass CPB Dexmedetomidine Acute kidney injury Renal interlobar arteries Vasoconstriction
Accesso online:	https://doi.org/10.1186/s40635-025-00836-7
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