Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome

BackgroundShiga toxin-producing Escherichia coli is the main cause of post-diarrheal hemolytic uremic syndrome (HUS), which produces acute kidney injury mainly in children. Shiga toxin exerts its action by binding to the glycolipid globotriaosylceramide (Gb3) on the cell surface of target tissues. I...

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Principais autores:	Daiana S. Sánchez, Lilian K. Fischer Sigel, Elsa Zotta, Claudia Silberstein
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-02-01
Series:	Frontiers in Pharmacology
Assuntos:	eliglustat globotriaosylceramide receptor glucosylceramide synthase inhibitor hemolytic uremic syndrome renal tubular injury prevention Shiga toxin type 2
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1736204/full
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