Eliglustat prevents acute kidney injury caused by Shiga toxin 2 in lethal and sublethal rat models of hemolytic uremic syndrome

BackgroundShiga toxin-producing Escherichia coli is the main cause of post-diarrheal hemolytic uremic syndrome (HUS), which produces acute kidney injury mainly in children. Shiga toxin exerts its action by binding to the glycolipid globotriaosylceramide (Gb3) on the cell surface of target tissues. I...

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Autors principals:	Daiana S. Sánchez, Lilian K. Fischer Sigel, Elsa Zotta, Claudia Silberstein
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-02-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	eliglustat globotriaosylceramide receptor glucosylceramide synthase inhibitor hemolytic uremic syndrome renal tubular injury prevention Shiga toxin type 2
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1736204/full
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