The GENDULF algorithm: mining transcriptomics to uncover modifier genes for monogenic diseases

Abstract Modifier genes are believed to account for the clinical variability observed in many Mendelian disorders, but their identification remains challenging due to the limited availability of genomics data from large patient cohorts. Here, we present GENDULF (GENetic moDULators identiFication), o...

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Detalhes bibliográficos

Principais autores:	Noam Auslander, Daniel M Ramos, Ivette Zelaya, Hiren Karathia, Thomas O. Crawford, Alejandro A Schäffer, Charlotte J Sumner, Eytan Ruppin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Springer Nature 2020-12-01
coleção:	Molecular Systems Biology
Assuntos:	cystic fibrosis digenic inheritance gene expression modifier gene spinal muscular atrophy
Acesso em linha:	https://doi.org/10.15252/msb.20209701
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