The GENDULF algorithm: mining transcriptomics to uncover modifier genes for monogenic diseases

Abstract Modifier genes are believed to account for the clinical variability observed in many Mendelian disorders, but their identification remains challenging due to the limited availability of genomics data from large patient cohorts. Here, we present GENDULF (GENetic moDULators identiFication), o...

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Autors principals:	Noam Auslander, Daniel M Ramos, Ivette Zelaya, Hiren Karathia, Thomas O. Crawford, Alejandro A Schäffer, Charlotte J Sumner, Eytan Ruppin
Format:	Artigo
Idioma:	Inglês
Publicat:	Springer Nature 2020-12-01
Col·lecció:	Molecular Systems Biology
Matèries:	cystic fibrosis digenic inheritance gene expression modifier gene spinal muscular atrophy
Accés en línia:	https://doi.org/10.15252/msb.20209701
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